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Cohort studyClinical & experimental ophthalmology · 2026

Lessons Learnt From 25 Years of Endophthalmitis: Causes, Microbiology and Visual Outcome Trends.

Zelia K Chiu, Rosie C H Dawkins, Gursimrat K Bhullar … Penelope J Allen

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OphthalmologyCohort study

Nearly half of endophthalmitis cases ended with severely impaired final vision

Lessons Learnt From 25 Years of Endophthalmitis: Causes, Microbiology and Visual Outcome Trends.

Zelia K Chiu … Penelope J Allen

Clinical & experimental ophthalmology · 2026

Background

We aimed to study the trends in microbiology, precipitating causes and outcomes of endophthalmitis in Victoria, Australia, over a 25-year period.

Purpose

We aimed to study the trends in microbiology, precipitating causes and outcomes of endophthalmitis in Victoria, Australia, over a 25-year period.

Methods

We conducted a prospective study of all endophthalmitis cases to the Royal Victorian Eye and Ear Hospital, a state-wide tertiary referral centre for ocular conditions, thereby capturing nearly all state-wide endophthalmitis cases.

n = 1423 eyes

Results

vision checks showed nearly half ended severely impaired - worse outcome

BCVA <6/60

44.99%

BCVA ≥6/12

30.6%

More results

The mean (SD) age was 71.35 (16.12).

Cataract surgery formed the plurality of annual cases until 2009; intravitreal injections exceeded following.

More results

The rate of endophthalmitis secondary to cataract surgery decreased from 0.29%-0.02% over the 25-year period, with a significant decrease following the introduction of prophylactic cefazolin; however, the rate of endophthalmitis secondary to intravitreal injections remained relatively stable (0.01%-0.04%).

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Conclusion · 1 of 2

This study demonstrated declining rates of endophthalmitis secondary to cataract surgery and stable rates of endophthalmitis secondary to intravitreal injections.

Conclusion · 2 of 2

Visual outcomes were bimodal; while many do very poorly, some have good visual recovery.

Post

Lessons Learnt From 25 Years of Endophthalmitis: Causes, Microbiology and Visual Outcome Trends.

Nearly half of endophthalmitis cases ended with severely impaired final vision

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