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New research · Ophthalmology
Pediatric blood & cancer · 1d
Cohort studyPediatric blood & cancer · 2026

Survival Outcomes and Complications Among Canadian Children With Retinoblastoma: A Population-Based Report From CYP-C.

Samuel Sassine, Ofélie Trudeau-Ferrin, Caroline Laverdière … Hallie Coltin
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OphthalmologyCohort study

Canadian children with retinoblastoma had excellent 5-year survival overall.

Survival Outcomes and Complications Among Canadian Children With Retinoblastoma: A Population-Based Report From CYP-C.

Samuel Sassine … Hallie Coltin
Pediatric blood & cancer · 2026
Background

Retinoblastoma (retinoblastoma) is the most common pediatric ocular cancer, yet population-based data on survival and risk factors remain limited.

Purpose

This study aimed to describe survival in a large national retinoblastoma cohort and identify predictors of death and complications.

Methods

We performed a retrospective, population-based cohort study using the Cancer in Young People in Canada database of all children diagnosed with retinoblastoma from 2001 to 2019.

n = 484 patients
94.2%
Results
94.2%
children checked over 5 years - this share were still alive
n = 484 patients
More results

Among the 484 patients, the median age at diagnosis was 1.2 years (interquartile range: 0.4-2.2).

Eight (1.7%) patients had metastatic disease at diagnosis, and 273 (56.4%) underwent enucleation.

Overall, 96.1% of patients in the cohort were alive at last follow-up.

More results

The prevalence of grade 3 and 4 complications was 4.8% across the entire cohort (n = 31 events, n = 23 patients).

“
Conclusion

This large population-based study reported few complications in children with retinoblastoma but highlighted key survival disparities among non-White patients and patients with metastatic disease.

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