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New research · Ophthalmology
Melanoma research · 1d
Cohort studyMelanoma research · 2026

Ultrasonographic and histopathological correlation in choroidal melanoma: survival outcomes from a single-center study in Serbia.

Dolika D Vasović, Dejan M Rašić, Bojana Dačić-Krnjaja … Ivan Marjanović
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OphthalmologyCohort study

Ultrasound-measured tumor thickness closely matches histopathology findings in choroidal melanoma.

Ultrasonographic and histopathological correlation in choroidal melanoma: survival outcomes from a single-center study in Serbia.

Dolika D Vasović … Ivan Marjanović
Melanoma research · 2026
Purpose

To compare ultrasonographic and histopathological measurements of tumor size in enucleated eyes with choroidal melanoma and to evaluate the prognostic significance of tumor dimensions and morphological characteristics in a Serbian cohort.

Methods

Were followed for a minimum of 1 year, with some monitored for up to 5 years.

n = 59 patients
Results
0.843
ultrasound thickness readings closely matched actual tumor thickness measured after surgery
n = 59 patients
More results

The mean ultrasonographic base diameter and thickness were 14.63 ± 3.98 and 10.34 ± 3.54 mm, respectively, compared with 18.04 ± 6.54 and 10.55 ± 3.72 mm on pathology.

More results

Bland-Altman analysis demonstrated good agreement for tumor thickness (mean difference 0.2 mm; limits of agreement -5.5 to +5.5 mm) and acceptable agreement for base diameter (mean difference 3.4 mm; limits -8.2 to +15.1 mm).

Pathological thickness correlated significantly with shorter metastasis-free survival ( r = -0.293, P = 0.024).

“
Conclusion

Survival patterns in this cohort align with international data, highlighting the relevance of tumor thickness and morphology and emphasizing the value of data from an underrepresented region.

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