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Cohort studyCardiovascular and interventional radiology · 2026

Intra-Arterial Chemotherapy for Advanced Intraocular Retinoblastoma….

Sena Bozer Uludağ, Emre Can Çelebioğlu, Emre Utkan Büyükceran … Sadık Bilgiç

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OphthalmologyCohort study

Vision was maintained or improved in most eyes after intra-arterial chemotherapy for retinoblastoma.

Intra-Arterial Chemotherapy for Advanced Intraocular Retinoblastoma….

Sena Bozer Uludağ … Sadık Bilgiç

Cardiovascular and interventional radiology · 2026

Purpose

To evaluate the safety and efficacy of intra-arterial chemotherapy as a treatment for advanced intraocular retinoblastoma and to present our single-center experience.

Methods

This single-center retrospective cohort study included 13 pediatric patients (15 eyes) who underwent intra-arterial chemotherapy between January 2020 and December 2024.

n = 15 eyes

93.3%

Results

93.3%

vision stayed the same or got better in almost all eyes treated

n = 15 eyes

More results

According to the ICRB classification, most eyes (66.7%) were Groups D, followed by groups C and E.

The mean age at presentation was 22.5 months.

Minor procedural complications were observed in 8.8% of sessions, with no serious systemic adverse events.

More results

No patients required enucleation, and no cases of metastasis or death occurred during follow-up.

“

Conclusion · 1 of 2

Intra-arterial chemotherapy is a technically feasible and promising globe-sparing treatment for intraocular retinoblastoma, demonstrating high technical success and a favorable safety profile in our cohort.

Conclusion · 2 of 2

While preliminary outcomes show preserved visual function and high ocular survival, larger studies with longer follow-up are necessary to confirm long-term efficacy and safety within a multidisciplinary framework.

Post

Intra-Arterial Chemotherapy for Advanced Intraocular Retinoblastoma….

Vision was maintained or improved in most eyes after intra-arterial chemotherapy for retinoblastoma.

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