Histopathological characteristics of secondary enucleation after iodide-125 plaque radiotherapy in Chinese patients with uveal melanoma.
Nearly half of secondary enucleations after radiotherapy were due to tumor local control failure.
Histopathological characteristics of secondary enucleation after iodide-125 plaque radiotherapy in Chinese patients with uveal melanoma.
To explore the histopathological characteristics in eyes with uveal melanoma (uveal melanoma) that had secondary enucleation after iodine-125 plaque radiotherapy (plaque radiotherapy).
We retrospectively examined the histopathological features of enucleated ocular tissues to investigate microscopic differences based on treatment methods and reasons for secondary enucleation.
Compared with 124 primary enucleations, eyes after plaque radiotherapy were more likely to show tumour diffuse distribution; had more tumour cell necrosis and more inflammation.
In addition, eyes after plaque radiotherapy had a higher frequency of sclera invasion, optic nerve invasion by the tumour and neovascularisation of the iris.
Compared with eyes enucleated because of severe radiotherapy complications, eyes enucleated for local control failure had tumours invading the optic disc and ciliary body more frequently, pathological mitosis and the proportion of tumour diffuse distribution were higher.
By observing the pathological features, we regrouped the patients who underwent secondary enucleation after plaque radiotherapy.
These differences in histopathology may represent tissue effects of radiotherapy radiation or features related to tumour progression and growth.
Tumour insensitivity and progression after plaque radiotherapy clearly increased the risk of metastasis-related death. Some pathological microscopic features may be important prognostic indicators of patients with uveal melanoma.