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Cohort studyOcular oncology and pathology · 2026

Treatment Delay and Risk of Orbital Exenteration in Periocular Sebaceous Carcinoma.

Grant M Welk, Caroline Y Yu, Rachel Israilevich … Andrea A Tooley

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OphthalmologyCohort study

Longer delay to treatment linked to higher odds of orbital exenteration in sebaceous carcinoma

Treatment Delay and Risk of Orbital Exenteration in Periocular Sebaceous Carcinoma.

Grant M Welk … Andrea A Tooley

Ocular oncology and pathology · 2026

Background

This single-institution study characterizes outcomes in periocular sebaceous carcinoma and evaluates whether treatment delay is associated with orbital exenteration.

Methods

Retrospective case series of all patients diagnosed with primary periocular sebaceous carcinoma between January 1, 2000, and December 31, 2022, at a single academic institution.

n = 25 patients

Results

each 3-month treatment delay raised the risk of losing the eye

OR 1.16 (95% CI 1.01 to 1.38)

null 1

1.01

1.38

CI excludes the null - significant

More results

The study included 25 patients (median age 76.6 years).

Mean time from presentation-to-treatment was 5.67 months (range 0.26-28.52 months), with a subset experiencing prolonged delays.

Local tumor recurrence occurred in 4 (16%) at a median of 26.46 months.

More results

Overall survival was 54.2% at 10 years, with no deaths attributed to sebaceous carcinoma.

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Conclusion · 1 of 2

Treatment delay was associated with increased odds of orbital exenteration and not with measured socioeconomic factors.

Conclusion · 2 of 2

These findings suggest a potential relationship between time-to-treatment and extent of surgical management, with possible implications for vision preservation and quality of life.

Post

Treatment Delay and Risk of Orbital Exenteration in Periocular Sebaceous Carcinoma.

Longer delay to treatment linked to higher odds of orbital exenteration in sebaceous carcinoma

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