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Cohort studyOcular oncology and pathology · 2026

Extraocular Extension in Melanoma at an Ocular Oncology Unit in Buenos Aires.

Carolina Gentile, Maria Valentina Ranno, Stephany Loraine Lucia Salcedo Camargo … Paola De la Iglesia Niveyro

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OphthalmologyCohort study

Extrascleral tumor spread occurred in 6.62% of uveal melanoma patients studied.

Extraocular Extension in Melanoma at an Ocular Oncology Unit in Buenos Aires.

Carolina Gentile … Paola De la Iglesia Niveyro

Ocular oncology and pathology · 2026

Background

Extrascleral extension (EOE) of uveal melanoma is a known negative prognostic factor, more frequently observed in medium to large tumors.

Purpose

This study aimed to estimate the incidence of EOE in patients with uveal melanoma and analyze the prognosis of patients treated at the Italian Hospital of Buenos Aires from 2007 to June 2024.

Methods

With EOE at diagnosis or during follow-up were identified.

n = 181 patients

Results

6.62%

cancer cells spread beyond the eye's outer wall in a small share of patients

n = 181 patients

More results

The mean age was 64.41 years (SD 14.39).

Six patients (50%) had EOE at diagnosis (average tumor thickness 9.51 mm, average diameter 17.7 mm), while six developed it during follow-up.

The median time to event was 31.5 months (range: 8-120 months).

More results

Among these 12 patients, three developed metastases within the first year after diagnosis and treatment.

“

Conclusion

EOE is a poor prognostic factor and tends to occur in larger tumors. It may be present at diagnosis or appear years later, reinforcing the need for long-term surveillance. Early identification is crucial to ensure appropriate treatment.

Post

Extraocular Extension in Melanoma at an Ocular Oncology Unit in Buenos Aires.

Extrascleral tumor spread occurred in 6.62% of uveal melanoma patients studied.

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