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Case reportFrontiers in ophthalmology · 2026

Orbital metastasis from breast carcinoma: structured literature review and report of four cases.

Christian Kim, Mica Bergman, Roxana Fu … Michael A Burnstine

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OphthalmologyCase report

Orbital metastasis was the first sign of breast cancer in 43% of cases.

Orbital metastasis from breast carcinoma: structured literature review and report of four cases.

Christian Kim … Michael A Burnstine

Frontiers in ophthalmology · 2026

Background

Breast carcinoma is the most commonly diagnosed cancer worldwide and represents the most common primary tumor metastasizing to the orbit.

Purpose

Breast carcinoma is the most commonly diagnosed cancer worldwide and represents the most common primary tumor metastasizing to the orbit.

Methods

Of 220 records screened, 63 articles (29%) met inclusion criteria.

n = 220 records

Results

43%

In 30 of 69 patients, eye-socket spread was noticed before the breast cancer itself was diagnosed.

n = 220 records

More results

Sixty-nine cases of breast carcinoma metastatic to the orbit from 63 articles were reviewed.

The majority of patients were female (66 of 69, 96%).

The average age at presentation of orbital symptoms was 60 years.

In 15 of 69 patients (22%), orbital metastasis was initially diagnosed as a different orbital process.

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Conclusion · 1 of 2

Breast carcinoma, including metastatic disease, is increasingly characterized by improved survival and prolonged disease control in selected patients with advances in systemic therapy.

Conclusion · 2 of 2

In patients with a history of breast cancer, metastatic disease should be considered in those presenting with orbital pathology. Conversely, unexplained orbital findings may warrant evaluation for occult malignancy.

Post

Orbital metastasis from breast carcinoma: structured literature review and report of four cases.

Orbital metastasis was the first sign of breast cancer in 43% of cases.

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