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Cohort studyFrontiers in immunology · 2026

Ophthalmic involvement in VEXAS syndrome and its influence on mortality: insights from the international AIDA network registry.

Jurgen Sota, Andrea Hinojosa-Azaola, Eduardo Martín-Nares … Claudia Fabiani

OphthalmologyCohort study

Eye involvement in VEXAS syndrome independently predicts higher odds of death

Ophthalmic involvement in VEXAS syndrome and its influence on mortality: insights from the international AIDA network registry.

Jurgen Sota … Claudia Fabiani

Frontiers in immunology · 2026

Background

Orbital inflammation is the most common presentation of VEXAS, with any orbital structure potentially affected.

OR 3.72

Results

OR 3.72

eye involvement nearly quadruples the odds of dying

More results

Non-sight-threatening and uncomplicated anterior non-granulomatous uveitis and anterior diffuse scleritis follow in frequency, along with episcleritis.

Treatment of ophthalmic involvement showed full or partial response to glucocorticosteroids alone in 66.7% of cases.

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Conclusion

Ophthalmic involvement is common in VEXAS syndrome and signals a poorer prognosis in terms of mortality, highlighting the need for close monitoring.

Post

Ophthalmic involvement in VEXAS syndrome and its influence on mortality: insights from the international AIDA network registry.

Eye involvement in VEXAS syndrome independently predicts higher odds of death

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