XEN45 stent accounted for most reported minimally invasive glaucoma surgery-related endophthalmitis cases
Endophthalmitis in XEN45 Gel Stent: Case report and review of the literature.
William Xu … Jinghua Chen
SAGE open medical case reports · 2026
Background
This is a care of endophthalmitis following XEN45 Gel Stent implantation managed with combined corneal transplant and pars plana vitrectomy, and to review reported cases of endophthalmitis after minimally invasive glaucoma surgery.
58%
Results
58%
of 45 minimally invasive glaucoma surgery infections, most followed this specific stent
n = 45 minimally invasive glaucoma
More results
A 67-year-old male with primary open-angle glaucoma developed endophthalmitis 2 months after XEN45 implantation.
Cultures grew Streptococcus gordonii .
This is the first reported case of XEN45 Gel Stent-associated endophthalmitis which was successfully controlled with combined keratoplasty and vitrectomy.
More results
Potential risk factors included the XEN45 stent's susceptibility to exposure after conjunctival erosion, pool water exposure, and ab externo insertion during implantation.
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Conclusion
In cases of XEN45 Gel Stent-associated endophthalmitis, corneal transplant with pars plana vitrectomy could be a successful strategy to control infection and spare the globe.