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New research · Ophthalmology
Immunological medicine · 2d
Case-controlImmunological medicine · 2026

Risk factors for adverse events or use of high-potency corticosteroids in non-infectious uveitis: a Japan claims database study (J-CAT2).

Sentaro Kusuhara, Koh-Hei Sonoda, Toshikatsu Kaburaki … Hiroshi Goto
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OphthalmologyCase-control

Two or more sub-Tenon's steroid eye injections linked to higher odds of glaucoma treatment

Risk factors for adverse events or use of high-potency corticosteroids in non-infectious uveitis: a Japan claims database study (J-CAT2).

Sentaro Kusuhara … Hiroshi Goto
Immunological medicine · 2026
Purpose

The J-CAT2 study (#jRCT1030240195) aimed to evaluate treatment and patient factors associated with risk of complications/adverse events (adverse events) or high corticosteroid exposure in patients with non-infectious uveitis (non-infectious uveitis) using advanced quantitative and visual analytical approaches.

Methods

With non-infectious uveitis treatment-related claims (2016-2023) were included ( n = 98,842).

n = 98,842
Results

two or more sub-Tenon's steroid eye injections meant much higher odds of needing glaucoma treatment

OR 5.54 (95% CI 4.03 to 7.60)
null 1
4.03
7.60
CI excludes the null - significant
More results

The study included data from a nationwide insurance claims database in Japan.

A nested case-control design was used to evaluate patient factors associated with complications/adverse events or high corticosteroid exposure.

Macular edema was the most likely factor associated with ≥2 sub-Tenon injections.

More results

The J-CAT2 study used a novel, quantitative and visual framework to understand associations between dose, frequency, and duration of corticosteroid treatment and complications/adverse events risk in non-infectious uveitis.

“
Conclusion

These findings suggest that optimization of corticosteroid administration protocols and exploration of alternative therapeutic strategies/targeted treatment approaches are necessary to mitigate complication risks.

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