Exogenous Fusarium Endophthalmitis: Clinical Features, Treatment Modalities, and Visual Outcomes.

StudyInvestigative ophthalmology & visual science· Jun 2026

Exogenous Fusarium Endophthalmitis: Clinical Features, Treatment Modalities, and Visual Outcomes.

Sujin Kang, William E Smiddy, Nicolas A Yannuzzi … Harry W Flynn

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UveitisStudyPrognosisQ1IF 4.2

Only 29% achieved decent vision after treatment for Fusarium eye infection.

Exogenous Fusarium Endophthalmitis: Clinical Features, Treatment Modalities, and Visual Outcomes.

Sujin Kang … Harry W Flynn

Investigative ophthalmology & visual science · Jun 2026 · Q1 in Ophthalmology

Purpose

To characterize the clinical features, treatment modalities, and visual outcomes of culture-proven exogenous Fusarium endophthalmitis managed at a tertiary referral center.

Methods

This retrospective, single-center, consecutive case series included 14 eyes of 14 patients with culture-proven exogenous Fusarium endophthalmitis treated between October 2014 and December 2025.

n = 14 eyes

29%

Results

29%

less than a third of patients regained functional, usable eyesight

n = 14 eyes

More results

Median presenting best-corrected visual acuity (BCVA) was 2.40 logMAR (∼20/5000).

Infection sources included trauma (7/14, 50%), anterior segment surgery (5/14, 36%), and contact lens-associated fungal keratitis (2/14, 14%).

More results

All eyes required combined antifungal therapy (topical, intravitreal, intracameral, and/or intrastromal with systemic treatment) and surgical intervention, including therapeutic penetrating keratoplasty (14/14, 100%) and vitrectomy (8/14, 57%).

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Conclusion · 1 of 2

Exogenous Fusarium endophthalmitis is a serious ocular infection requiring multimodal therapy and multiple surgical interventions, yet long-term visual outcomes remain poor.

Conclusion · 2 of 2

Early fungal recognition and prompt antifungal treatment may improve outcome.

Exogenous Fusarium Endophthalmitis: Clinical Features, Treatment Modalities, and Visual Outcomes.

Exogenous Fusarium Endophthalmitis: Clinical Features, Treatment Modalities, and Visual Outcomes.

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