Comparative Efficacy of Type I Interferons and Monoclonal Antibodies in Experimental Autoimmune Uveitis: A…

Animal / preclinicalOcular immunology and inflammation· Jul 2026

Comparative Efficacy of Type I Interferons and Monoclonal Antibodies in Experimental Autoimmune Uveitis: A Systematic Review and Meta-Analysis.

Armand Ceniza, Skyler Colwell, Wesley Burrow, Jorge Cervantes

UveitisAnimal / preclinicalQ2IF 1.7

Monoclonal antibodies reduced eye inflammation far more than interferons in uveitis models.

Comparative Efficacy of Type I Interferons and Monoclonal Antibodies in Experimental Autoimmune Uveitis: A Systematic Review and Meta-Analysis.

Armand Ceniza … Jorge Cervantes

Ocular immunology and inflammation · Jul 2026 · Q2 in Ophthalmology

Background

Experimental autoimmune uveitis (experimental autoimmune uveitis) is an animal model of non-infectious uveitis used to study immune-mediated ocular inflammation.

Purpose

This study aimed to compare the therapeutic effects of these treatments in experimental autoimmune uveitis.

Methods

PRISMA guidelines were followed for systematic review and meta-analysis (PROSPERO ID-1320794).

Results

antibody treatment shrank eye inflammation far more than interferon treatment did

Hedges' g -3.09 (95% CI -3.70 to -2.47)

CI excludes the null - significant

More results

Type I interferon therapy significantly reduced eye inflammation scores compared with controls (SMD = -0.68, p < 0.001) but did not significantly reduce histologic inflammation (SMD ≈ -0.55, p = 0.25).

Meta-regression showed no relationship between interferon dose/frequency and treatment efficacy.

More results

Both therapies reduce experimental autoimmune uveitis inflammation, but monoclonal antibodies demonstrate greater efficacy.

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Conclusion

These findings suggest that targeted cytokine or co-stimulatory pathway inhibition demonstrated larger anti-inflammatory effects than interferon-mediated immunomodulation in preclinical experimental autoimmune uveitis models, though clinical applicability remains uncertain.

Comparative Efficacy of Type I Interferons and Monoclonal Antibodies in Experimental Autoimmune Uveitis: A Systematic Review and Meta-Analysis.

Comparative Efficacy of Type I Interferons and Monoclonal Antibodies in Experimental Autoimmune Uveitis: A Systematic Review and Meta-Analysis.

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