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StudyJournal of radiation research · 2026

Dosimetric feasibility of carbon-ion radiotherapy for ocular melanomas with local effect model-based treatment planning system.

Yuze Yang, Jiayao Sun, Xue Ming … Yinxiangzi Sheng

DermatologyStudy

A conversion factor of 0.65 was needed to adapt carbon-ion radiotherapy dose planning for eye melanoma.

Dosimetric feasibility of carbon-ion radiotherapy for ocular melanomas with local effect model-based treatment planning system.

Yuze Yang … Yinxiangzi Sheng

Journal of radiation research · 2026

Purpose

This study evaluates the dosimetric feasibility of carbon-ion radiation therapy (carbon-ion radiation therapy) for ocular melanoma (ocular melanoma) using a local effect model-I-based treatment planning system (treatment planning system) combined with pencil beam scanning delivery.

0.65

Results

0.65

converts standard dose planning to match this therapy - lower means a smaller adjusted dose

More results

The 3D gamma passing rate between treatment planning system and MC was ≥94% using 3%-3 mm criteria.

Mean dose deviations between the treatment planning system and measurement were ≤±1.61% for all targets sizes except the smallest one (7 mm).

More results

Mean distance-to-agreement was <1 mm for all plans except one with a range shifter (distance-to-agreement = 2.92 mm).

Phantom cases showed a lateral penumbra of 5.4-6.2 mm, and distal dose fall-off measures 3.6 and 5.6 mm.

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Conclusion

The results underscore the need for relative biological effectiveness-weighted dose conversion when applying Quantum Science and Technology's carbon-ion radiation therapy experience to ocular melanoma treatment.

Post

Dosimetric feasibility of carbon-ion radiotherapy for ocular melanomas with local effect model-based treatment planning system.

A conversion factor of 0.65 was needed to adapt carbon-ion radiotherapy dose planning for eye melanoma.

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