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New research · Ophthalmology
Ophthalmology science · 2d
Animal / preclinicalOphthalmology science · 2026

Topotecan Microneedle Scleral Patch: A Transscleral Drug Delivery Study for Retinoblastoma.

Vishal Raval, R Arawindh, Sharayu Naik … Venkata Vamsi Krishna Venuganti
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OphthalmologyAnimal / preclinical

Microneedle scleral patch delivered topotecan selectively to the retina in rabbits

Topotecan Microneedle Scleral Patch: A Transscleral Drug Delivery Study for Retinoblastoma.

Vishal Raval … Venkata Vamsi Krishna Venuganti
Ophthalmology science · 2026
Purpose

We aimed to design, fabricate, and evaluate the pharmacokinetic properties of topotecan loaded with microneedle scleral patch (microneedle scleral patch) in rabbit eye.

Methods

The microneedle scleral patch was fabricated using a 3-dimensional printed master mold.

n = 9 eyes
Results

retina held far more drug than blood, showing highly targeted delivery

275fold
MSP
58.9fold
Intra-arterial chemoth
1.32fold
Intravenous chemothera
More results

The dimensions of microneedles were uniform across the array measuring 548 ± 3.7 μm length, 336 ± 7.5 μm width, and 18 μm tip diameter.

In the ex vivo goat eye model, the required insertion force was 0.026 N per needle, which was 50 times lower than the compression strength of 1.27 N per needle.

More results

The microneedles were inserted up to a depth of 225 μm.

At 8 hours, the drug level was undetectable (0.02 ± 0.01 μg/g).

“
Conclusion · 1 of 2

A single topotecan-loaded microneedle scleral patch (100 μg) achieved highly selective retinal tissue distribution, with a retinal-to-plasma ratio of 275-fold, which was 4.7-fold higher than intra-arterial chemotherapy (58.9) and 209-fold higher than intravenous chemotherapy (1.32), supporting its potential benefit for RB treatment.

Conclusion · 2 of 2

FINANCIAL

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