Association between Nicotine and Cannabis Use and Ocular Inflammatory Diseases and Complications: Results from the TriNetX Database.
Cannabis use is associated with more than double the odds of scleritis
Association between Nicotine and Cannabis Use and Ocular Inflammatory Diseases and Complications: Results from the TriNetX Database.
To analyze the incidence of ocular inflammatory diseases and related ocular complications in patients with and without a history of cigarette, cannabis, vaping, and chewing tobacco use or exposure to tobacco smoke.
Aged 18 years and older with and without a history of cigarette, vape, cannabis, or chewing tobacco use, patients with and without a history of exposure to second-hand smoke, and patients with a diagnosis of an ocular inflammatory disease were included in our study.
cannabis users had more than double the odds of developing scleritis
Compared to nonsmokers, the OR for developing uveitis was 1.459 times higher for cannabis users ( P = 0.016, 95% confidence interval [CI]: 1.072-1.985) and 1.712 times higher for those exposed to tobacco smoke ( P < 0.001, 95% CI: 1.366-2.146).
The odds of developing oMMP were 1.923 times higher for cigarette users ( P = 0.042, 95% CI: 1.011-3.657).
The odds of developing glaucoma were 1.551 times higher for cigarette users ( P < 0.001, 95% CI: 1.234-1.95), 1.547 times higher for vape users ( P < 0.002, 95% CI: 1.223-1.956), 1.574 times higher for chewing tobacco users ( P < 0.001, 95% CI: 1.25-1.982), and 1.707 times higher for those exposed to tobacco smoke ( P = 0.001, 95% CI: 1.229-2.37).
History of cannabis use and exposure to second-hand smoke are significantly associated with an increased risk of uveitis, whereas a history of chewing tobacco, vape, and cannabis use is significantly associated with an increased risk of scleritis.
Cigarette use is also associated with a significantly increased risk of oMMP.