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New research · Ophthalmology
The British journal of ophthalmology · 2d
Cohort studyThe British journal of ophthalmology · 2026

Incidence of bilateral disease and choroidal neovascularisation in punctate inner choroiditis.

Paulina Liberman, Jay R Maturi, Jennifer E Thorne … Douglas A Jabs
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OphthalmologyCohort study

Immunosuppression is associated with lower odds of active choroidal neovascularization in this condition.

Incidence of bilateral disease and choroidal neovascularisation in punctate inner choroiditis.

Paulina Liberman … Douglas A Jabs
The British journal of ophthalmology · 2026
Purpose

To characterise the incidence of bilateral involvement and choroidal neovascularisation (choroidal neovascularisation) in punctate inner choroiditis (punctate inner choroiditis).

Methods

Retrospective, single-centre case series of 52 patients with punctate inner choroiditis evaluated at a tertiary referral centre in the USA.

n = 73 eyes
Results

immunosuppression cuts the odds of active neovascularization

OR 0.50 (95% CI 0.27 to 0.93)
null 1
0.27
0.93
CI excludes the null - significant
More results

At diagnosis, 31/52 patients (59.6%) had unilateral disease.

During follow-up, 11 developed fellow-eye involvement (0.08/person-year; 95% CI 0.04 to 0.13), with the highest incidence within 5 years of diagnosis (0.20/person-year; 95% CI 0.09 to 0.36).

At diagnosis, choroidal neovascularisation was present in 34/73 eyes (46.6%).

More results

During follow-up, 20 eyes developed incident choroidal neovascularisation (0.06/eye-year; 95% CI 0.04 to 0.10), highest within 5 years of diagnosis (0.14/eye-year; 95% CI 0.08 to 0.22).

“
Conclusion · 1 of 2

Punctate inner choroiditis frequently presents unilaterally but carries risk of bilateral progression. choroidal neovascularisation is common at presentation and is a cause of vision loss.

Conclusion · 2 of 2

Immunosuppression is associated with reduced odds of active choroidal neovascularisation.

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