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Cross-sectionalAmerican journal of ophthalmology · 2026

Corneal Sensitivity Changes and Nerve Plexus Abnormalities in Noninfectious Anterior Uveitis.

Yuyuan Zhou, Lei Lin, Mali Dai … Wei Chen

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OphthalmologyCross-sectional

Uveitis-affected eyes had markedly reduced corneal sensitivity versus healthy eyes

Corneal Sensitivity Changes and Nerve Plexus Abnormalities in Noninfectious Anterior Uveitis.

Yuyuan Zhou … Wei Chen

American journal of ophthalmology · 2026

Purpose

This study evaluated the structural and functional alterations of corneal nerves in unilateral noninfectious anterior uveitis patients.

Methods

Affected eyes were assigned to the affected group, contralateral clinically unaffected eyes to the unaffected group, and eyes from 25 healthy subjects to the control group.

Results

eyes touched to check how well they felt it: uveitis eyes needed much stronger touch to notice

β -6.09 (95% CI -7.44 to -4.74)

null 0

-7.44

-4.74

CI excludes the null - significant

More results

Moreover, compared with controls, affected eyes exhibited significantly lower corneal nerve parameters, notably CNFL (β = -6.09; 95% CI, -7.44 to -4.74), alongside higher inflammatory cell density and microneuroma counts (all adjusted P < .001).

More results

Relative to controls, unaffected eyes also demonstrated measurable differences, including higher noncontact corneal aesthesiometer thresholds, reduced CNFL, CNFD, and CFracDim, as well as increased microneuroma counts (all adjusted P < .010).

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Conclusion

Unilateral noninfectious anterior uveitis was associated with reduced corneal nerve sensitivity and altered nerve parameters in the affected eye, and measurable differences in the contralateral eye.

Post

Corneal Sensitivity Changes and Nerve Plexus Abnormalities in Noninfectious Anterior Uveitis.

Uveitis-affected eyes had markedly reduced corneal sensitivity versus healthy eyes

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