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ReviewPediatric rheumatology online journal · 2026

Identifying outcome measures for clinical trials in juvenile idiopathic arthritis associated uveitis for the MIWGUC proposal: a scoping review to create domains from existing outcome measures.

Ilaria Maccora, Giulia Inguscio, Stefano Romano … Gabriele Simonini

OphthalmologyReview

Studies use 15 different outcome measures to track juvenile arthritis-related eye inflammation.

Identifying outcome measures for clinical trials in juvenile idiopathic arthritis associated uveitis for the MIWGUC proposal: a scoping review to create domains from existing outcome measures.

Ilaria Maccora … Gabriele Simonini

Pediatric rheumatology online journal · 2026

Background

Chronic anterior uveitis represents the most important extra-articular manifestation of Juvenile Idiopathic Arthritis (Juvenile Idiopathic Arthritis).

Methods

We performed a systematic literature review from 1st January 2019 to 28th February 2025 to identify studies investigating outcome measures used in Juvenile Idiopathic Arthritis-associated uveitis (Juvenile Idiopathic Arthritis-U), according to PRISMA guidelines.

n = 37 studies

15

Results

15

researchers checked eye inflammation in different, inconsistent ways across studies

n = 37 studies

More results

We identified 261 papers, of whom 90 potentially eligible.

Based on their characteristics, we categorized them into three different subgroups: outcome measures for disease activity (30 studies); outcome measures correlated to structural damage (29 studies); and outcome measures of severe disease course (20 studies).

More results

Compared with the 2019 review, we identified four studies reporting novel objective techniques for inflammation assessment, including laser flare photometry and anterior segment optical coherence tomography.

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Conclusion · 1 of 2

Our review confirms the variety of outcome measures for JIA-associated uveitis while highlighting the emergence of novel imaging and biomarker-based measures.

Conclusion · 2 of 2

These findings provide an updated evidence base for revising the core outcome set and emphasize the urgent need for a consensus and a composite score, which are essential both for designing endpoints in clinical trials and for guiding treatment choices in clinical practice.

Post

Identifying outcome measures for clinical trials in juvenile idiopathic arthritis associated uveitis for the MIWGUC proposal: a scoping review to create domains from existing outcome measures.

Studies use 15 different outcome measures to track juvenile arthritis-related eye inflammation.

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