Age-related changes in central corneal thickness and their association with ocular biometric parameters in…

Cohort studyFrontiers in medicine· 2026

Age-related changes in central corneal thickness and their association with ocular biometric parameters in children.

Qing Yuan, Yawen Bai, Zhe Su … Yan Lu

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CorneaCohort studyDiagnosisQ1IF 3.4

Corneal thickness rises slightly with age in children before stabilizing at 13.

Age-related changes in central corneal thickness and their association with ocular biometric parameters in children.

Qing Yuan … Yan Lu

Frontiers in medicine · 2026 · Q1 in General Medicine

Purpose

To investigate age-related changes in central corneal thickness (central corneal thickness) and its relationship with ocular biometric parameters in children.

Methods

This retrospective study included 393 children (786 eyes) examined using ZEISS IOLMaster 700 to measure central corneal thickness, axial length (axial length), corneal curvature (Km), anterior chamber depth (anterior chamber depth), and lens thickness (lens thickness).

n = 786 eyes

r = 0.150

Results

r = 0.150

corneal thickness measurements barely tracked with children's age

n = 786 eyes

More results

The cohort comprised 192 males (48.8%) and 201 females (51.2%) with a mean age of 9.5 ± 3.1 years and mean central corneal thickness of 551.53 ± 32.93 μm.

No significant correlation was found with sex or lens thickness.

More results

Longitudinally, central corneal thickness increased significantly over 1 year in children aged 3-12 years, with no significant change in those aged 13-17.

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Conclusion · 1 of 2

Central corneal thickness increases with age in children aged 3-12 years and stabilizes after 13 years.

Conclusion · 2 of 2

Thinner central corneal thickness is associated with myopia and steeper corneal curvature, informing pediatric eye assessment, myopia management, and orthokeratology safety.

Age-related changes in central corneal thickness and their association with ocular biometric parameters in children.

Age-related changes in central corneal thickness and their association with ocular biometric parameters in children.

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