Hallermann-Streiff syndrome: A systematic review of the published literature.

ReviewJournal of oral biology and craniofacial research· Jul 2026

Hallermann-Streiff syndrome: A systematic review of the published literature.

Rezhat Abbas, Revathi Krishna, Aarushi Garg

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Micrognathia is the most common craniofacial feature of Hallermann-Streiff syndrome.

Hallermann-Streiff syndrome: A systematic review of the published literature.

Rezhat Abbas … Aarushi Garg

Journal of oral biology and craniofacial research · Jul 2026

Background

Hallermann-Streiff syndrome is an extremely rare congenital disorder characterized by craniofacial dysmorphism, ocular abnormalities, hypotrichosis, and mandibular hypoplasia, frequently associated with complex airway challenges.

Methods

A systematic search of PubMed, Scopus, Embase, and ScienceDirect identified 42 records following PRISMA 2020 guidelines.

n = 42 records

Results

checked for a small lower jaw - found in nearly all cases

Congenital cataracts

76%

Microphthalmia

65%

Strabismus

59%

Micrognathia

88%

More results

Ophthalmologic abnormalities were common, including congenital cataracts (76%), microphthalmia (65%), and strabismus (59%).

One report documented three-generation familial inheritance.

Interventions were multidisciplinary, with most cases showing partial improvement, although severe neonatal respiratory failure remained fatal.

“

Conclusion

Hallermann-Streiff syndrome presents with a characteristic triad of craniofacial, airway, and ophthalmologic abnormalities requiring coordinated multidisciplinary care and long-term follow-up.

Hallermann-Streiff syndrome: A systematic review of the published literature.

Hallermann-Streiff syndrome: A systematic review of the published literature.

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