Post

New research · Ophthalmology
Translational vision science & technology · 2d
Animal / preclinicalTranslational vision science & technology · 2026

Automated Deep Learning Quantification of Avascular Area and Intravitreal Neovascularization in Retinal Flatmounts of Rodent Oxygen-Induced Retinopathy Models.

Neal S Shah, Aniket Ramshekar, Bright Asare-Bediako … M Elizabeth Hartnett
Read paper
OphthalmologyAnimal / preclinical

Reviewers preferred the AI model's neovascularization outlines in most comparisons

Automated Deep Learning Quantification of Avascular Area and Intravitreal Neovascularization in Retinal Flatmounts of Rodent Oxygen-Induced Retinopathy Models.

Neal S Shah … M Elizabeth Hartnett
Translational vision science & technology · 2026
Purpose

To develop a single deep learning model that quantifies the retinal avascular area (avascular area) and intravitreal neovascularization (intravitreal neovascularization) in rodent oxygen-induced retinopathy (oxygen-induced retinopathy) models.

Methods

We assessed intergrader reliability and agreement at metric and pixel levels.

n = 325 images
83.3%
Results
83.3%
Human reviewers picked the deep-learning model's abnormal blood vessel outline as best in 83.3% of comparisons.
n = 325 images
More results

Intergrader reliability was high for percent avascular area (mouse intraclass correlation coefficient [ICC] = 0.840; rat ICC = 0.971), moderate for rat percent intravitreal neovascularization (ICC = 0.509), and low for mouse percent intravitreal neovascularization (ICC = -0.082).

More results

Metric-level correlation was strong in rat oxygen-induced retinopathy (percent avascular area r = 0.979; percent intravitreal neovascularization r = 0.943) and for mouse percent avascular area (r = 0.957), but weak for mouse percent intravitreal neovascularization (r = 0.265).

“
Conclusion

Our deep learning model supports automated rat oxygen-induced retinopathy analysis while maintaining mouse performance and may improve reproducibility of oxygen-induced retinopathy measurements.

Read paper
0 comments

No comments yet. Be the first.

Related papers

LatestFoundational
Cross-sectional
44.1%
had too much homocysteine in the blood, a far larger share than in dry AMD or healthy eyes
Cohort Study
92.3%
most laser-treated eyes had a favorable eye-structure outcome
Cohort Study
56%
lost three or more lines on the eye-chart vision test
Cohort Study
50%
older patients were more likely to lose three or more lines of vision
Study
81%
trials where mask air leaks were detected blowing toward the eyes
Cohort Study
13.5%
Central retinal artery peak blood-flow speed was 13.5% lower in diabetic patients.
Study
379 +/- 156 microm
lower thickness in the central retina, checked with an eye scan
Case Report
9 of 10 eyes
eyes had better measured vision after treatment