Localized and sustained release of Botulinum Toxin A from supramolecular peptide hydrogel for strabismus…

Animal / preclinicalTheranostics· 2026

Localized and sustained release of Botulinum Toxin A from supramolecular peptide hydrogel for strabismus treatment.

Wei Guo, Hui Zhu, Yuchen Yao … Hu Liu

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Pediatric OphthalmologyAnimal / preclinical

Peptide hydrogel delivery boosts local retention of botulinum toxin A near injection site.

Localized and sustained release of Botulinum Toxin A from supramolecular peptide hydrogel for strabismus treatment.

Wei Guo … Hu Liu

Theranostics · 2026

Background

Botulinum toxin type A (BTXA) is an injectable neurotoxin widely used for the nonsurgical treatment of strabismus.

Methods

In this research, we co-assembled a pentapeptide hydrogelator Nap-Phe-Phe-Lys-Lys-Lys (NapFFKKK) with BTXA under mild physiological conditions to form a supramolecular hydrogel Gel Nap+BTXA for localized and sustained release of BTXA.

3.1-fold

Results

3.1-fold

Hydrogel delivery kept far more toxin concentrated at the muscle injection site.

More results

Furthermore, Gel Nap+BTXA effectively alleviated ptosis and provided more stable and long-lasting ocular alignment correction up to 2 months, with no detectable ocular or systemic toxicity.

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Conclusion

This study demonstrated a safe and efficient localized delivery strategy for BTXA, offering a promising alternative for strabismus treatment.

Localized and sustained release of Botulinum Toxin A from supramolecular peptide hydrogel for strabismus treatment.

Localized and sustained release of Botulinum Toxin A from supramolecular peptide hydrogel for strabismus treatment.

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