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New research · Ophthalmology
BMJ open ophthalmology · 2d
Randomized trialBMJ open ophthalmology · 2026

Diffractive optical element (D.O.E) spectacle lenses for myopia prevention and control: a small-scale pilot study among younger Chinese children.

Xiaofeng Zhu, Qiurong Lin, Tao Sun … Wei Xu
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OphthalmologyRandomized trial

Diffractive lenses slightly slowed myopia progression versus comparison lenses in children

Diffractive optical element (D.O.E) spectacle lenses for myopia prevention and control: a small-scale pilot study among younger Chinese children.

Xiaofeng Zhu … Wei Xu
BMJ open ophthalmology · 2026
Purpose

To assess the efficacy and safety of diffractive optical element (D.

Methods

Were randomly assigned to wear either the D.

n = 19
Results

myopia worsened slightly less with diffractive lenses than comparison lenses

MD 0.20 (95% CI 0.07 to 0.33)
null 0
0.07
0.33
CI excludes the null - significant
More results

After 3 months, compared with the H.

E group exhibited significantly smaller changes in cycloplegic spherical equivalent refraction (p<0.001), a significant reduction in axial length (p=0.024) and a significantly greater increase in choroidal thickness (p=0.009).

The estimated least-squares mean differences (95% CIs) compared with the H.

More results

No significant differences were observed between the groups regarding compliance or subjective evaluation.

“
Conclusion · 1 of 3

D. O. E spectacle lenses used in this pilot study demonstrated a statistically significant, though not clinically meaningful, effect in slowing myopia progression among younger Chinese children.

Conclusion · 2 of 3

The primary limitations were the small sample size and the short observation period, which restricted the ability to detect clinically significant changes.

Conclusion · 3 of 3

These findings are preliminary and require further validation before they can inform clinical decision-making.

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