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ObservationalWiadomosci lekarskie (Warsaw, Poland : 1960) · 2026

Factors affecting the progression of glaucomatous optic neuropathy after antiglaucoma surgery in patients with primary open-angle glaucoma.

Iryna V Shargorodska, Sergiy O Rykov, Yurii V Barinov … Nataliia M Aleieva

OphthalmologyObservational

Thinner neuroretinal rim before surgery strongly linked to worsening glaucoma nerve damage afterward

Factors affecting the progression of glaucomatous optic neuropathy after antiglaucoma surgery in patients with primary open-angle glaucoma.

Iryna V Shargorodska … Nataliia M Aleieva

Wiadomosci lekarskie (Warsaw, Poland : 1960) · 2026

Purpose

To identify and analyze the key clinical, structural, and functional factors influencing the progression of glaucomatous optic neuropathy after antiglaucoma surgical intervention in patients with POAG, as well as to determine their prognostic value for optimizing postoperative patient management.

Methods

A retrospective observational cohort study included 56 patients (56 operated eyes) with primary open‑angle glaucoma who underwent unilateral antiglaucoma surgery and were followed dynamically in the postoperative period.

n = 56 patients

Results

smaller optic-nerve rim tissue before surgery meant much higher progression odds

OR by subgroup · 95% CI

More results

Postoperative disease progression was not associated with age, sex, axial length, or phacomorphic syndrome.

Besides, disease progression was significantly associated with elevated plasma LOX1 concentration (≥ 80.1 pg/mL), reduced neuroretinal rim area (< 0.7 mm²), and elevated preoperative IOP (> 25 mmHg).

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Conclusion · 1 of 2

Conclusions: Postoperative progression of glaucomatous optic neuropathy in patients with primary open‑angle glaucoma is determined by a combination of structural, biomechanical, and systemic vascular‑related factors.

Conclusion · 2 of 2

Preoperative IOP, neuroretinal rim morphology, and plasma LOX1 levels have prognostic significance and should be considered for postoperative risk stratification and individualized follow‑up.

Factors affecting the progression of glaucomatous optic neuropathy after antiglaucoma surgery in patients with primary open-angle glaucoma.

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