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Cohort studyInvestigative ophthalmology & visual science · 2026

Lens Opacity in ABCA4-Associated Stargardt Disease Patients in the ProgStar Study.

Folahan Ibukun, Bai Xi Jasmine Chan, Jehanzeb Khan … Xiangrong Kong

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OphthalmologyCohort study

Older age strongly linked to lens opacity in Stargardt disease patients

Lens Opacity in ABCA4-Associated Stargardt Disease Patients in the ProgStar Study.

Folahan Ibukun … Xiangrong Kong

Investigative ophthalmology & visual science · 2026

Purpose

The purpose of this study was to estimate lens opacity (lens opacity) and associated risk factors in patients with ABCA4 associated Stargardt disease (STGD1).

Methods

With molecularly confirmed STGD1 aged ≥6 years from the United States and Europe were enrolled and followed for 2 years.

n = 354 eyes

Results

each decade older meant much higher odds of cloudy lens

adjOR 4.60 (95% CI 2.60 to 7.90)

null 0

2.60

7.90

CI excludes the null - significant

More results

Of the 259 participants, 54% were women, 86% were Caucasian, and the median age of STGD1 symptom onset was 19 years.

At baseline, median age = 31 (interquartile range [IQR] = 21-44, range = 6-68) years; lens opacity prevalence = 14.3% (69/483) of study eyes.

More results

Among the 354 eyes without lens opacity at baseline, 2-year incidence was 5.6%.

Older age was associated with incidence: adjOR for every decade older = 4.1 (95% CI = 1.8-9.1).

“

Conclusion · 1 of 2

Lens opacity prevalence in ProgStar is higher than in age-matched general population. Age and age of symptom onset were risk factors of lens opacity, suggesting both biological and accelerated aging due to retinal degeneration in STGD1.

Conclusion · 2 of 2

Trials of STGD1 should closely monitor safety in the anterior segment and consider excluding patients expecting cataract surgery soon.

Post

Lens Opacity in ABCA4-Associated Stargardt Disease Patients in the ProgStar Study.

Older age strongly linked to lens opacity in Stargardt disease patients

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