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New research · Ophthalmology
Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2d
StudyQuality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2026

Mapping the NEI-VFQ-25 scores to the EQ-5D-Y-3L and CHU-9D utility values among adolescents with myopia.

Chang Luo, Mingxing Liu, Rongjie Shao … Jing Wu
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OphthalmologyStudy

Vision-related quality-of-life scores correlate only weakly with EQ-5D-Y-3L in myopic teens

Mapping the NEI-VFQ-25 scores to the EQ-5D-Y-3L and CHU-9D utility values among adolescents with myopia.

Chang Luo … Jing Wu
Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2026
Purpose

To develop mapping algorithms for predicting EQ-5D-Y-3L and CHU-9D utility values from the National Eye Institute 25-Item Visual Function Questionnaire (NEI-VFQ-25) among adolescents with myopia to support economic evaluation.

Methods

Data were collected from 2,198 adolescents with myopia in China.

n = 2,198 adolescents
Results

vision-related quality of life only weakly tracks teens' overall health status

CHU-9D
0.5r
EQ-5D-Y-3L
0.37r
More results

The mean (SD) utility values were 0.962 (0.070) for the EQ-5D-Y-3L and 0.851 (0.160) for the CHU-9D.

More results

The ordinary least squares and generalized linear model using stepwise-selected subscale scores demonstrated the best predictive performance for EQ-5D-Y-3 L (mean absolute error = 0.045, RMSE = 0.061, absolute error > 0.05 [%] = 30.37%) and CHU-9D (mean absolute error = 0.103, RMSE = 0.139, absolute error > 0.05 [%] = 61.50%), respectively.

“
Conclusion · 1 of 2

This study established algorithms for estimating EQ-5D-Y-3L and CHU-9D utility values based on NEI-VFQ-25 subscale scores for adolescents with myopia, thus facilitating future economic evaluation for myopia interventions.

Conclusion · 2 of 2

However, given the limited conceptual overlap between the NEI-VFQ-25 and EQ-5D-Y-3L, the EQ-5D-Y-3L algorithm should be applied with caution.

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