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New research · Ophthalmology
Eye (London, England) · 2d
Cohort studyEye (London, England) · 2026

Association of accelerometer-monitored physical activity with incident cataract: epidemiological and genetic evidence.

Chenxiao Shen, Jiahui Cao, Zijing Du … Honghua Yu
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OphthalmologyCohort study

More moderate-to-vigorous exercise per week was linked to lower risk of age-related cataract

Association of accelerometer-monitored physical activity with incident cataract: epidemiological and genetic evidence.

Chenxiao Shen … Honghua Yu
Eye (London, England) · 2026
Purpose

To investigate the association and potential causal relationship between accelerometer-assessed physical activity (physical activity) and the risk of senile cataract (senile cataract).

Methods

Furthermore, two-sample Mendelian randomisation (mendelian randomisation) analyses were conducted using genome-wide association data from multiple large-scale prospective study cohorts (UK Biobank for physical activity and FinnGen for senile cataract) to elucidate potential causality.

n = 77,123 participants
Results

150-600 min/week of moderate-to-vigorous exercise linked to lower cataract risk

HR 0.79 (95% CI 0.68 to 0.91)
null = 10.680.91
CI excludes the null - significant
More results

The study ultimately enrolled 77,123 participants with a mean age of 55.67 ± 7.8 years.

Dose-response analyses revealed U-shaped associations for MPA and MVPA, with the lowest risk observed at moderate volumes.

More results

For other intensities, engaging in ≥300 min/week of MPA was associated with reduced risk (HR = 0.78, 95% CI: 0.66-0.92), while no significant associations were observed for LPA or VPA alone.

“
Conclusion

Adhering to the physical activity guidelines established by the World Health Organization emerges as a novel and modifiable protective measure to delay the progression of senile cataract.

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