Corneal endothelial morphology in patients with herpetic keratitis attending tertiary eye centre.

Cross-sectionalBMC ophthalmology· Jul 2026

Corneal endothelial morphology in patients with herpetic keratitis attending tertiary eye centre.

Barsha Kumari Singh, Sanjeeta Sitaula, Sanjeev Bhattarai … Prakash Jha

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CorneaCross-sectionalPrognosisQ2IF 2.2

Herpetic keratitis is associated with lower corneal endothelial cell density in affected eyes

Corneal endothelial morphology in patients with herpetic keratitis attending tertiary eye centre.

Barsha Kumari Singh … Prakash Jha

BMC ophthalmology · Jul 2026 · Q2 in Ophthalmology

Background

Herpetic keratitis is a common cause of infectious corneal disease and can result in long term visual morbidity.

Purpose

This study aimed to evaluate and compare corneal endothelial morphology, including endothelial cell density, cell size variability, and hexagonality, between eyes affected by herpetic keratitis and their contralateral unaffected eyes.

Methods

This hospital-based cross-sectional comparative study included 39 patients with unilateral herpetic keratitis, comprising 39 affected eyes and 39 contralateral unaffected eyes.

n = 39 patients

Results

endothelial cell count was lower in the infected eye than the healthy eye

Affected eyes

2555.38cells/

Unaffected eyes

2879cells/

More results

Central corneal thickness did not differ significantly between affected and contralateral unaffected eyes.

“

Conclusion

Eyes with unilateral herpetic keratitis demonstrated reduced corneal endothelial cell density and hexagonality, along with increased variability in cell size compared with contralateral unaffected eyes, indicating corneal endothelial alterations associated with the disease.

Corneal endothelial morphology in patients with herpetic keratitis attending tertiary eye centre.

Corneal endothelial morphology in patients with herpetic keratitis attending tertiary eye centre.

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