Risk of Cataract and Ocular Hypertension in Chronic Anterior Uveitis Patients on Stable-Dosing of Topical…

Cohort studyOcular immunology and inflammation· Jul 2026

Risk of Cataract and Ocular Hypertension in Chronic Anterior Uveitis Patients on Stable-Dosing of Topical Corticosteroids.

Nicholas J Butler, Maxwell Pistilli, Kurt A Dreger … SITE Cohort Study Research Group

GlaucomaCohort studyTreatmentQ2IF 1.7

Using one or fewer steroid eye drops daily was not linked to excess cataract risk.

Risk of Cataract and Ocular Hypertension in Chronic Anterior Uveitis Patients on Stable-Dosing of Topical Corticosteroids.

Nicholas J Butler … SITE Cohort Study Research Group

Ocular immunology and inflammation · Jul 2026 · Q2 in Ophthalmology

Purpose

To assess the association of cataract progression and intraocular pressure (IOP) elevation with stable-dosing of topical corticosteroid for chronic anterior uveitis (chronic anterior uveitis).

Methods

All patients with chronic anterior uveitis from the Systemic Immunosuppressive Therapy for Eye Diseases Cohort treated with topical prednisolone 1% or equipotent equivalent for at least six months were analyzed.

n = 346 patients

Results

eyes at this lower dose showed no higher rate of new cataracts

aHR 0.91 (95% CI 0.29 to 2.84)

CI crosses the null - not significant

More results

For the incident cataract outcome, 346 patients met the eligibility criteria.

Similarly, higher daily topical corticosteroid exposure conferred greater risk of both IOP outcomes, though plateau effects were observed.

More results

For eyes receiving ≤1 drop daily of prednisolone 1% or equivalent, there was no excess risk of either IOP outcome [aHR for ≥21 mmHg, 0.77 (95% CI, 0.19, 3.05) and aHR for ≥30 mmHg, 0.92 (95% CI, 0.11, 7.76)].

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Conclusion

Stable-dosing of topical prednisolone 1% or equivalent more than once daily was associated with increased cataract formation and IOP elevation over medium-term follow-up, whereas ≤1 drop/day was not.

Risk of Cataract and Ocular Hypertension in Chronic Anterior Uveitis Patients on Stable-Dosing of Topical Corticosteroids.

Risk of Cataract and Ocular Hypertension in Chronic Anterior Uveitis Patients on Stable-Dosing of Topical Corticosteroids.

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