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New research · Ophthalmology
Ocular immunology and inflammation · 2d
Cohort studyOcular immunology and inflammation · 2026

Risk of Cataract and Ocular Hypertension in Chronic Anterior Uveitis Patients on Stable-Dosing of Topical Corticosteroids.

Nicholas J Butler, Maxwell Pistilli, Kurt A Dreger … SITE Cohort Study Research Group
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OphthalmologyCohort study

Using one or fewer steroid eye drops daily was not linked to excess cataract risk.

Risk of Cataract and Ocular Hypertension in Chronic Anterior Uveitis Patients on Stable-Dosing of Topical Corticosteroids.

Nicholas J Butler … SITE Cohort Study Research Group
Ocular immunology and inflammation · 2026
Purpose

To assess the association of cataract progression and intraocular pressure (IOP) elevation with stable-dosing of topical corticosteroid for chronic anterior uveitis (chronic anterior uveitis).

Methods

All patients with chronic anterior uveitis from the Systemic Immunosuppressive Therapy for Eye Diseases Cohort treated with topical prednisolone 1% or equipotent equivalent for at least six months were analyzed.

n = 346 patients
Results

eyes at this lower dose showed no higher rate of new cataracts

aHR 0.91 (95% CI 0.29 to 2.84)
null = 10.292.84
CI crosses the null - not significant
More results

For the incident cataract outcome, 346 patients met the eligibility criteria.

Similarly, higher daily topical corticosteroid exposure conferred greater risk of both IOP outcomes, though plateau effects were observed.

More results

For eyes receiving ≤1 drop daily of prednisolone 1% or equivalent, there was no excess risk of either IOP outcome [aHR for ≥21 mmHg, 0.77 (95% CI, 0.19, 3.05) and aHR for ≥30 mmHg, 0.92 (95% CI, 0.11, 7.76)].

“
Conclusion

Stable-dosing of topical prednisolone 1% or equivalent more than once daily was associated with increased cataract formation and IOP elevation over medium-term follow-up, whereas ≤1 drop/day was not.

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