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New research · Ophthalmology
American journal of ophthalmology · 2d
Cohort studyAmerican journal of ophthalmology · 2026

Ocular Response Analyzer versus Goldmann Applanation Tonometry in a Population-based Sample: The Thessaloniki Eye Study.

Rodanthi Christina Bartzoulianou, Anne L Coleman, M Roy Wilson … Fotis Topouzis
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OphthalmologyCohort study

Switching eye pressure test to IOPcc raised high-pressure diagnosis rate 8-fold.

Ocular Response Analyzer versus Goldmann Applanation Tonometry in a Population-based Sample: The Thessaloniki Eye Study.

Rodanthi Christina Bartzoulianou … Fotis Topouzis
American journal of ophthalmology · 2026
Purpose

To compare corneal-compensated intraocular pressure (IOPcc) with Goldmann applanation tonometry (GAT-IOP) in an elderly cohort and assess effects of substituting GAT-IOP with IOPcc on IOP distribution, ocular hypertension prevalence, glaucoma screening, and risk modeling.

Methods

One eye from 854 participants in the 12-year incidence phase of the Thessaloniki Eye Study.

n = 854 participants
Results

high eye pressure readings jumped 8-fold when the newer test method was used

OR by subgroup · 95% CI
null = 1
stronger effect size for GAT-IOP
1.26
than for IOPcc
1.18
More results

Mean age was 79.2 (SD 3.9) years; 42.4% were female.

GAT-IOP was associated with central corneal thickness (central corneal thickness) (95% CI, 0.009-0.022; p=0.02), whereas IOPcc was not (95% CI, -0.001 to 0.016; p=0.08).

AUCs were similar (0.818 vs 0.780; p=0.31).

More results

In multivariable models, IOP measures were independently associated with glaucoma, with stronger effect size for GAT-IOP (OR=1.264; 95% CI, 1.182-1.359) than for IOPcc (OR=1.176; 95% CI, 1.116-1.241); pseudoexfoliation, family history, and body mass index were significant in both models, whereas central corneal thickness and axial length were significant only in the GAT-IOP model.

“
Conclusion

Substituting GAT-IOP with IOPcc changed risk estimates, while the measures are not interchangeable and standard IOPcc thresholds may overestimate ocular hypertension.

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