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AI / informaticsClinical ophthalmology (Auckland, N.Z.) · 2026

Corneal Tomography Changes After Simultaneous Topical Application of Cyclosporine and Trehalose in Keratoconus Evaluated with an Artificial Intelligence Model.

Rohit Shetty, Pooja Khamar, Gairik Kundu … Abhijit Sinha Roy

OphthalmologyAI / informatics

AI analysis confirmed corneal shape stayed stable in most keratoconus eyes.

Corneal Tomography Changes After Simultaneous Topical Application of Cyclosporine and Trehalose in Keratoconus Evaluated with an Artificial Intelligence Model.

Rohit Shetty … Abhijit Sinha Roy

Clinical ophthalmology (Auckland, N.Z.) · 2026

Purpose

To assess corneal tomography changes in keratoconus (keratoconus) patients after long-term simultaneous use of topical cyclosporine and trehalose.

Methods

Corneal tomography of 362 eyes with keratoconus was performed using Pentacam (OCULUS Optikgerate Gmbh, Germany) at 1 st visit and at the last follow-up.

n = 362 eyes

Results

AI check found the eye's front surface shape held steady, not worsening

90%

Initial classification

95%

Final classification (

More results

Based on a change in Kmax of 0.75, 1.0 and 1.25D criteria, more than 90% of the eyes were stable for each criterion at the last follow-up (initial classification).

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Conclusion

Most keratoconus eyes had stable tomography findings between the first and last follow-up. Topical anti-inflammatory regimens may be useful for minimizing or eliminating keratoconus progression.

Post

Corneal Tomography Changes After Simultaneous Topical Application of Cyclosporine and Trehalose in Keratoconus Evaluated with an Artificial Intelligence Model.

AI analysis confirmed corneal shape stayed stable in most keratoconus eyes.

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