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Case-controlClinical & experimental ophthalmology · 2026

Comparative Study of Trabeculectomy, PRESERFLO MicroShunt and XEN45 Gel Stent in Open-Angle Glaucoma.

Marie-Isaline Billen Moulin-Romsée, Thomas Jacobs, Rafael Correia Barão … Ingeborg Stalmans

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OphthalmologyCase-control

XEN Gel Stent had lower 1-year complete success than trabeculectomy or PRESERFLO.

Comparative Study of Trabeculectomy, PRESERFLO MicroShunt and XEN45 Gel Stent in Open-Angle Glaucoma.

Marie-Isaline Billen Moulin-Romsée … Ingeborg Stalmans

Clinical & experimental ophthalmology · 2026

Background

To compare the safety and efficacy of trabeculectomy, PRESERFLO MicroShunt (PRESERFLO) and XEN45 Gel Stent (XEN) in patients with open-angle glaucoma (open-angle glaucoma) during the first year.

Methods

A single-centre retrospective case-control study included 384 eyes undergoing standalone glaucoma surgery (2013-2020).

n = 384 eyes

Results

trabeculectomy and PRESERFLO controlled eye pressure far more often than XEN

Trabeculectomy

59.8%

PRESERFLO

73.5%

XEN

44%

More results

We included 117 in the trabeculectomy, 82 eyes in the PRESERFLO group and 185 in the XEN group.

All procedures effectively and comparably reduced IOP to 12.3 ± 4.1 mmHg (trabeculectomy), 12.7 ± 3.5 mmHg (PRESERFLO), 13.4 ± 4.3 mmHg (XEN).

Significant hypotony was uncommon and comparably so.

More results

Minor post-operative interventions were more common in trabeculectomy patients compared with PRESERFLO and XEN.

“

Conclusion · 1 of 2

This study suggests equal success rates for PRESERFLO and trabeculectomy, both outperforming XEN at 1 year, with fewer post-operative interventions for PRESERFLO compared to trabeculectomy.

Conclusion · 2 of 2

Overall complication rates were comparable across groups.

Post

Comparative Study of Trabeculectomy, PRESERFLO MicroShunt and XEN45 Gel Stent in Open-Angle Glaucoma.

XEN Gel Stent had lower 1-year complete success than trabeculectomy or PRESERFLO.

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