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AI / informaticsFrontiers in cell and developmental biology · 2026

Artificial intelligence assisted quantitative analysis of fundus structural and vascular alterations reveals fundus tessellation as a robust biomarker of myopia severity.

Luxiang Sun, Dongqing Yuan, Chenfeng Gu … Hong Cheng

OphthalmologyAI / informatics

Larger macular fundus tessellation area independently linked to high myopia

Artificial intelligence assisted quantitative analysis of fundus structural and vascular alterations reveals fundus tessellation as a robust biomarker of myopia severity.

Luxiang Sun … Hong Cheng

Frontiers in cell and developmental biology · 2026

Background

Myopia is characterized by progressive axial elongation and structural remodeling of the posterior segment, ultimately leading to irreversible visual impairment in high myopia.

Methods

This cross-sectional observational study included 539 eyes from 274 participants with varying degrees of myopia.

n = 539 eyes

OR = 2.925

Results

OR = 2.925

larger tessellated retina area strongly raised odds of high myopia

n = 539 eyes

More results

Fundus structural and vascular parameters showed significant differences across myopia severity groups.

Fundus tessellation-related parameters increased progressively with increasing myopia severity (all P < 0.001), with macular fundus tessellation area demonstrating the strongest association.

More results

Retinal vascular complexity and vessel density decreased with increasing myopia severity, reflected by reduced fractal dimensions and vessel density (all P < 0.001).

ROC analysis showed that macular fundus tessellation area achieved the highest discriminative performance (AUC = 0.819), and a combined model yielded an AUC of 0.869.

“

Conclusion · 1 of 3

Fundus structural alterations, particularly fundus tessellation and peripapillary atrophy, are the most robust imaging biomarkers associated with myopia severity.

Conclusion · 2 of 3

While refraction and axial length remain the primary measures of myopic severity, fundus tessellation provides complementary information about posterior segment remodeling.

Conclusion · 3 of 3

Prospective studies are needed to evaluate whether fundus tessellation predicts future complications such as myopic maculopathy or retinal detachment.

Post

Artificial intelligence assisted quantitative analysis of fundus structural and vascular alterations reveals fundus tessellation as a robust biomarker of myopia severity.

Larger macular fundus tessellation area independently linked to high myopia

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