Factors Associated With Progression to Primary Angle Closure: A Post Hoc Analysis of the ANA-LIS Trial.
Plateau iris configuration strongly linked to progression from narrow-angle suspect to angle closure
Factors Associated With Progression to Primary Angle Closure: A Post Hoc Analysis of the ANA-LIS Trial.
IMPORTANCE: Identifying primary angle closure suspect (primary angle closure suspect) eyes at higher risk of progressing to primary angle closure (primary angle closure) is clinically important.
To evaluate baseline anterior segment risk factors associated with progression from primary angle closure suspect to primary angle closure over 5 years.
This post hoc analysis involves data from a randomized clinical trial (Singapore Asymptomatic Narrow Angles-Laser Iridotomy Study) conducted at 5 tertiary eye hospitals from November 1, 2004, to October 31, 2018.
plateau iris in even one part of the eye raised progression risk over 11-fold
Of the 480 participants originally enrolled, 161 (33.5%) underwent baseline anterior segment optical coherence tomography and ultrasound biomicroscopy.
Among these participants, 123 (76.4%) were female and 38 (23.6%) male; the mean (SD) age was 62.9 (7.2) years.
Overall, 16 of 322 eyes (5.0%, 7 with laser peripheral iridotomy and 9 without laser peripheral iridotomy) progressed.
Narrower anterior chamber angles, plateau iris configuration in more than 1 quadrant, or higher baseline IOP were associated with greater risk of progression.