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New research · Ophthalmology
Cornea · 3d
StudyCornea · 2026

Long-term Infectious Keratitis Microbiology and Resistance Patterns With Forecasts to 2030: A 23-Year Analysis.

Guillermo Raul Vera-Duarte, Luis Haro-Morlett, Thelma Cortés-Moreno … Enrique O Graue-Hernandez
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OphthalmologyStudy

Positive corneal culture rates in infectious keratitis rose to about 80% over 23 years

Long-term Infectious Keratitis Microbiology and Resistance Patterns With Forecasts to 2030: A 23-Year Analysis.

Guillermo Raul Vera-Duarte … Enrique O Graue-Hernandez
Cornea · 2026
Purpose

To analyze 23-year trends in microbiology and antibiotic resistance among infectious keratitis (infectious keratitis) isolates at a tertiary center in Mexico City and to generate validated forecasts through 2030 to inform empiric therapy and stewardship.

Methods

Corneal scrapings were processed using standardized sampling, culture, and identification protocols; susceptibilities were interpreted per CLSI (VITEK and Kirby-Bauer).

n = 4748 cultures
80%
Results
80%
positive cultures were found far more often by the study's end
n = 4748 cultures
More results

Among 4748 cultures, 2918 (61.46%) were positive: bacteria 2624 (89.92%) and fungi 294 (10.08%).

Bacterial isolates were 81.44% Gram+ and 18.56% Gram-.

More results

The leading organisms were Staphylococcus epidermidis, other Gram+, other coagulase-negative staphylococci, Pseudomonas aeruginosa, and Staphylococcus aureus; Fusarium dominated fungi (52.38%).

Gram+ resistance declined in β-lactams/50S agents but increased for fluoroquinolones, vancomycin, and gentamicin.

“
Conclusion · 1 of 2

Infectious keratitis microbiology underwent a late-2000s reconfiguration followed by durable stabilization.

Conclusion · 2 of 2

Forecasts project continued stability with targeted resistance signals, supporting ongoing local surveillance, antimicrobial stewardship, and optimized diagnostic practices.

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