Short-term intraocular pressure changes following intravitreal injections of aflibercept 8mg versus 2mg: A prospective comparative study.

Both formulations produced significant IOP elevations from baseline at T1 and T2 ( p < 0.001 within each group).

No significant between-group differences were identified at any timepoint.

Pre-existing glaucoma/OHT was the only consistent independent predictor of both IOP >21 mmHg (OR 3.00-3.31, p = 0.024-0.038) and IOP elevation >5 mmHg from baseline (OR 10.45-11.75, p < 0.001) at T2; aflibercept formulation was not associated with either outcome.

No injection required paracentesis.