Bisphosphonates and glaucoma: a pharmacovigilance signal detection analysis using the FAERS database.

Subtype-level signals included alendronic acid with open-angle glaucoma (reporting odds ratio = 5.67) and normal-tension glaucoma (reporting odds ratio = 4.60); pamidronic acid with open-angle glaucoma (reporting odds ratio = 8.62); and risedronic acid with angle-closure glaucoma (reporting odds ratio = 2.93).

Median time-to-onset varied from 10 days (risedronic acid) to 1579 days (pamidronic acid).