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New research · Ophthalmology
Canadian journal of ophthalmology. Journal canadien d'ophtalmologie · 3d
StudyCanadian journal of ophthalmology. Journal canadien d'ophtalmologie · 2026

Bisphosphonates and glaucoma: a pharmacovigilance signal detection analysis using the FAERS database.

Yan Zhang, Yi Hong Huang, Yan Ling Xiao … Mao Sheng Guo
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OphthalmologyStudy

Alendronic acid (a bisphosphonate) is linked to more reported glaucoma cases in a safety database.

Bisphosphonates and glaucoma: a pharmacovigilance signal detection analysis using the FAERS database.

Yan Zhang … Mao Sheng Guo
Canadian journal of ophthalmology. Journal canadien d'ophtalmologie · 2026
Purpose

To detect and characterize disproportionality signals between individual bisphosphonates and glaucoma subtypes using the U.

Methods

Data were drawn from adverse event reports from the FAERS database (Q1 2004-Q1 2025).

n = 3 cases
Results

more reports of glaucoma diagnoses among people taking alendronic acid

ROR 2.42 (95% CI 2.18 to 2.70)
null = 02.182.70
CI excludes the null - significant
More results

Subtype-level signals included alendronic acid with open-angle glaucoma (reporting odds ratio = 5.67) and normal-tension glaucoma (reporting odds ratio = 4.60); pamidronic acid with open-angle glaucoma (reporting odds ratio = 8.62); and risedronic acid with angle-closure glaucoma (reporting odds ratio = 2.93).

More results

Median time-to-onset varied from 10 days (risedronic acid) to 1579 days (pamidronic acid).

“
Conclusion · 1 of 2

This pharmacovigilance analysis identifies distinct disproportionality signals linking specific bisphosphonates to different glaucoma subtypes, with heterogeneous time-to-onset patterns.

Conclusion · 2 of 2

The findings highlight potential safety signals warranting further clinical and mechanistic investigation.

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