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New research · Ophthalmology
American journal of ophthalmology · 3d
StudyAmerican journal of ophthalmology · 2026

Cultured Human Corneal Endothelial Cell Injection Therapy in Phakic Eyes with Bullous Keratopathy.

Rintaro Ogino, Akira Kobayashi, Mariko Shirane … Kazuno Negishi
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OphthalmologyStudy

Corneal cell injection therapy was associated with better vision in bullous keratopathy eyes

Cultured Human Corneal Endothelial Cell Injection Therapy in Phakic Eyes with Bullous Keratopathy.

Rintaro Ogino … Kazuno Negishi
American journal of ophthalmology · 2026
Purpose

To evaluate the safety and efficacy of cultured human corneal endothelial cell (cHCEC) injection therapy in phakic eyes with bullous keratopathy (bullous keratopathy), for which endothelial keratoplasty may accelerate cataract progression due to intraoperative manipulation and postoperative gas tamponade.

Methods

Five consecutive phakic eyes of 5 patients with bullous keratopathy who underwent cHCEC injection therapy and completed 6 months of follow-up.

n = 5 patients
Results

vision improved after treatment, judged by an eye-chart reading test

MD -0.84 (95% CI -1.32 to -0.36)
null = 0-1.32-0.36
CI excludes the null - significant
More results

Mean central corneal thickness (central corneal thickness) decreased from 782 ± 104 μm to 578 ± 61 μm (mean change, -204 μm; 95% CI, -306 to -102 μm; P = .005).

Corneal clarity improved in all eyes and remained stable throughout the 6-month follow-up.

More results

At 6 months, postoperative endothelial cell density ranged from 693 to 1622 cells/mm².

Mean intraocular pressure (IOP) changed from 10.1 ± 4.3 mm Hg to 11.7 ± 3.1 mm Hg (mean change, 1.54 mm Hg; 95% CI, -4.39 to 7.47 mm Hg; P = .511).

“
Conclusion · 1 of 2

cHCEC injection therapy demonstrated favorable short-term clinical outcomes in phakic eyes with bullous keratopathy and may represent a promising lens-preserving treatment option.

Conclusion · 2 of 2

Larger controlled studies with longer follow-up are warranted.

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