Photodynamic Therapy in Central Serous Chorioretinopathy: Treatment Timing, Anatomical Response, and…

Cohort studyOphthalmology and therapy· Jul 2026

Photodynamic Therapy in Central Serous Chorioretinopathy: Treatment Timing, Anatomical Response, and Recurrence in a Large Real-World Cohort.

Caroline M Stüven, Tina Herold, Paul Foerster … Benedikt Schworm

OphthalmologyCohort studyTreatmentQ1IF 4.2

Photodynamic therapy fully resolved subretinal fluid in about half of eyes.

Photodynamic Therapy in Central Serous Chorioretinopathy: Treatment Timing, Anatomical Response, and Recurrence in a Large Real-World Cohort.

Caroline M Stüven … Benedikt Schworm

Ophthalmology and therapy · Jul 2026 · Q1 in Ophthalmology

Background

Central serous chorioretinopathy (central serous chorioretinopathy) is characterized by pathological accumulation of subretinal fluid (subretinal fluid), leading to visual impairment.

Purpose

This study aimed to identify predictors of treatment response in a large cohort of patients with central serous chorioretinopathy treated with photodynamic therapy.

Methods

In this retrospective, single-center study, clinical characteristics and treatment outcomes of patients with central serous chorioretinopathy undergoing photodynamic therapy were systematically analyzed.

n = 115 patients

51.3%

Results

51.3%

Photodynamic therapy cleared retinal fluid entirely in about half of eyes checked

n = 115 patients

More results

Mean visual acuity improved by -0.02 ± 0.22 logMAR (p = 0.0047).

Recurrence occurred in 30% of eyes after a mean of 1.1 ± 1.1 years.

A significant negative correlation was observed between time to photodynamic therapy and central retinal thickness reduction (r = -0.286, p = 0.001) but not with visual acuity (p = 0.76).

More results

Repeat photodynamic therapy, performed in 16 eyes, resulted in further significant central retinal thickness reduction (p = 0.008).

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Conclusion · 1 of 2

Photodynamic therapy is effective in reducing subretinal fluid in central serous chorioretinopathy. Delayed treatment was associated with diminished anatomical response.

Conclusion · 2 of 2

Repeat photodynamic therapy may provide additional benefit in recurrent disease.

Photodynamic Therapy in Central Serous Chorioretinopathy: Treatment Timing, Anatomical Response, and Recurrence in a Large Real-World Cohort.

Photodynamic Therapy in Central Serous Chorioretinopathy: Treatment Timing, Anatomical Response, and Recurrence in a Large Real-World Cohort.

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