Post

New research · Ophthalmology
Scientific reports · 4d
Animal / preclinicalScientific reports · 2026

Biodegradable PLGA nanoparticles of acyclovir and an acyclovir prodrug for potential enhanced therapy against HSV-1 infection.

Sushruta S Hakkimane, Divakarareddy Vemanna Paladugulu, Santosh L Gaonkar … Bharath Raja Guru
Read paper
OphthalmologyAnimal / preclinical

Acyclovir prodrug PLGA nanoparticles released drug steadily for 28 days.

Biodegradable PLGA nanoparticles of acyclovir and an acyclovir prodrug for potential enhanced therapy against HSV-1 infection.

Sushruta S Hakkimane … Bharath Raja Guru
Scientific reports · 2026
Background

Herpes simplex virus-1 (HSV-1) is a widespread, recurrent infection that causes herpes simplex keratitis (herpes simplex keratitis), an ocular disease that can lead to vision impairment.

28
Results
28
days
drug kept releasing steadily this long before running out
More results

We developed an esterified acyclovir prodrug (acyclovir prodrug) formulated as biodegradable poly(lactic-co-glycolic acid) (PLGA) nanoparticles (nanoparticles) to improve stability, enable sustained release, and enhance antiviral activity against HSV-1.

More results

Optimized nanoparticles measured 200-300 nm with polydispersity indices of 0.23-0.47 and zeta potentials of - 27 to - 29 mV.

Cytotoxicity in Vero cells yielded CC50 values of 960 µM (ACY-NPs) and 1000 µM (ACPD-NPs).

“
Conclusion

Since corneal tissues contain esterase, its activation may improve acyclovir prodrug efficacy in in vivo models, which in turn increases bioavailability and overall therapeutic efficacy of acyclovir prodrug-NPs.

Read paper
0 comments

No comments yet. Be the first.

Related papers

LatestFoundational
AI / Informatics
0·962 for OCT
MerMED-FM was very accurate at diagnosing diseases using eye scans
AI / Informatics
0.98
Artificial intelligence's eyelid-height measurements matched doctors' manual measurements almost perfectly
AI / Informatics
92.1%
combining eye scans and photos correctly told benign from cancerous lesions apart nearly every time
Cohort Study
28.6%
recurred locally in more than 1 in 4 patients over years of follow-up
Cohort Study
-0.395
excision group's post-op eyelid fullness score was lower - greater improvement
Cohort Study
86.7%
of infants probed after 12 months still had unresolved tear duct blockage
Observational
16%
eyelid tissue in rosacea patients showed less of this key repair-signaling protein inside cell nuclei
Cohort Study
25%
about 1 in 4 treated cases had symptoms return after improving