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New research · Ophthalmology
Oral and maxillofacial surgery · 4d
Cohort studyOral and maxillofacial surgery · 2026

Survival outcomes after orbital exenteration for recurrent or previously treated orbital malignancies: impact of margin status and metastatic spread.

M Todaro, F Perquoti, F De Lorenzis … A Moro
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OphthalmologyCohort study

Positive surgical margins after orbital exenteration are associated with 0% 24-month survival.

Survival outcomes after orbital exenteration for recurrent or previously treated orbital malignancies: impact of margin status and metastatic spread.

M Todaro … A Moro
Oral and maxillofacial surgery · 2026
Background

Orbital exenteration is a radical procedure used in selected orbital malignancies, yet survival outcomes vary widely, particularly in recurrent or previously treated disease.

Methods

We retrospectively analyzed 39 patients who underwent orbital exenteration between 2017 and 2024.

n = 39 patients
Results
0%
positive tumor-margin tissue meant no patients survived 2 years
n = 39 patients
More results

Of the 39 patients, 24 (61.5%) had localized disease and 15 (38.5%) had advanced disease with nodal and/or distant metastasis; 6 patients (15.4%) had positive margins.

24-month OS was 78% in localized disease versus 33% in patients with nodal and/or distant metastasis (p = 0.011).

More results

Median OS was not reached in localized disease and was 13 months in patients with nodal and/or distant metastasis.

24-month DFS was 62.5% versus 33% (p = 0.017).

“
Conclusion · 1 of 3

Nodal and/or distant metastatic status and positive surgical margins were associated with worse survival outcomes after orbital exenteration for recurrent or previously treated orbital malignancies.

Conclusion · 2 of 3

Most adverse events occurred within the first postoperative year, suggesting a clinically relevant early risk period.

Conclusion · 3 of 3

Given the histological heterogeneity of the cohort, these findings should be interpreted as prognostic patterns in a salvage orbital oncology population and require validation in larger disease-specific series.

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