Efficacy and safety of procedural sedation-analgesia during laser photocoagulation for retinopathy of prematurity: a systematic review.

Primary outcome was analgesic efficacy (pain score reduction, rescue analgesics required).

Two reviewers extracted relevant information and assessed risk-of-bias using ROB2 and evidence certainty using GRADE methodology.

Of 540 articles screened, four relevant RCTs were identified (n = 265).

REVIEW REGISTRATION: Prospectively registered on PROSPERO (CRD420251070146).