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New research · Ophthalmology
Scientific reports · 4d
Randomized trialScientific reports · 2026

A multinational randomized clinical trial of an eye-tracking-based binocular amblyopia treatment in children aged 4-9 years.

Oren Yehezkel, Tamara Wygnanski-Jaffe, Burton J Kushner … The CureSight Pivotal Trial Group
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OphthalmologyRandomized trial

In children completing therapy, eye-tracking treatment improved vision more than patching

A multinational randomized clinical trial of an eye-tracking-based binocular amblyopia treatment in children aged 4-9 years.

Oren Yehezkel … The CureSight Pivotal Trial Group
Scientific reports · 2026
Purpose

This randomized controlled study compared efficacy and safety of a novel binocular, eye-tracking-based home amblyopia treatment (CureSight) to patching.

Methods

S.) enrolled 197 children aged 4 to < 9 years with anisometropic, small-angle strabismic, or mixed-mechanism amblyopia at 15 academic/community sites (modified intent-to-treat); 156 completed ≥ 60% of prescribed dosage (per-protocol).

n = 197 children
Results

kids using CureSight home therapy saw better vision gains than patchers

MD 0.03 (95% CI -0.01 to 0.06)
null = 0-0.010.06
CI crosses the null - not significant
More results

Three cohorts (China, Israel, U.

CureSight: 90 min/day, 5 days/week for 16 weeks (120 h); patching: 2 h/day, 7 days/week (224 h).

In the modified intent-to-treat dataset, visual acuity improvement from baseline to week 16 in the binocular group was noninferior to the patching group (0.028 logMAR; 95% CI - 0.007 to 0.063).

More results

There was no significant between-group difference in the magnitude of improvement in stereoacuity in either dataset.

“
Conclusion

Overall, CureSight was noninferior to patching in these amblyopia types and yielded better visual outcomes in children completing ≥ 60% dosage, supporting binocular therapy as an additional first-line option.

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