Probable linezolid-associated bilateral toxic optic neuropathy after prolonged therapy: A case report.

Case reportThe Journal of international medical research· Jul 2026

Probable linezolid-associated bilateral toxic optic neuropathy after prolonged therapy: A case report.

Si-Yu Chang, Chun-Xia Zhang, Yue Cong, Xu Li

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Neuro-ophthalmologyCase reportClinical practiceQ3IF 1.8

Long-term unsupervised linezolid use linked to optic nerve damage in both eyes.

Probable linezolid-associated bilateral toxic optic neuropathy after prolonged therapy: A case report.

Si-Yu Chang … Xu Li

The Journal of international medical research · Jul 2026 · Q3 in General Medicine

Background

A woman in her 30s was administered linezolid treatment for pneumonia.

9

Results

9

months

self-treatment lasted this long before eye damage appeared

More results

Visual field testing indicated the presence of central scotomas in both eyes.

Visual evoked potentials testing showed reduced amplitudes in both eyes.

After discontinuing linezolid, the patient's visual function gradually improved.

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Conclusion

This case suggests that close monitoring of visual function and neurological symptoms in patients receiving linezolid treatment is crucial, and early identification of relevant abnormalities and timely discontinuation of the drug can effectively improve patient prognosis.

Probable linezolid-associated bilateral toxic optic neuropathy after prolonged therapy: A case report.

Probable linezolid-associated bilateral toxic optic neuropathy after prolonged therapy: A case report.

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