Post-Marketing Ocular Adverse Events Associated with Tamoxifen and Raloxifene: A Population-Based Pharmacovigilance Study.

There were a total of 4,084 reports of adverse events associated with tamoxifen (mean age 56.7 years), including 505 ocular adverse events.

The strongest signals were for corneal graft rejection (reporting odds ratios 118.9), retrobulbar hemorrhage (104.6), ophthalmic vein thrombosis (82.7), retinal deposits (80.7), and macular hole (78.6).

Additional events included maculopathy, retinopathy, and optic neuropathy.

There were 5,600 reports of adverse events associated with raloxifene (mean age 68.6 years), including 437 ocular adverse events.