Enhanced detection of optic neuritis with contrast-enhanced 3D FLAIR in orbital MRI.

StudyNeuroradiology· Jul 2026

Enhanced detection of optic neuritis with contrast-enhanced 3D FLAIR in orbital MRI.

Etsushi Iida, Masahiro Tanabe, Atsuo Inoue … Katsuyoshi Ito

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Neuro-ophthalmologyStudyDiagnosisQ2IF 2.9

Adding a special MRI scan detected optic neuritis far more often in atypical cases.

Enhanced detection of optic neuritis with contrast-enhanced 3D FLAIR in orbital MRI.

Etsushi Iida … Katsuyoshi Ito

Neuroradiology · Jul 2026

Purpose

This study evaluates whether adding CE FS 3D FLAIR to standard orbital MRI improves diagnostic performance.

Methods

This retrospective single-center diagnostic accuracy study included 48 patients (mean age, 60 years ± 18; 30 women) clinically suspected of acute optic neuritis who underwent orbital MRI between September 2016 and July 2024.

n = 48 patients

76.9%

Results

76.9%

the extra scan correctly flagged optic neuritis in more atypical cases than usual MRI

n = 48 patients

More results

CE FS 3D FLAIR detected optic disc abnormalities in 18 of 55 symptomatic nerves (32.7%) compared with 11 of 55 (20.0%) on CE FS 3D T1WI.

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Conclusion

Adding CE FS 3D FLAIR to conventional orbital MRI significantly improves diagnostic accuracy for optic neuritis, especially in atypical clinical presentations.

Enhanced detection of optic neuritis with contrast-enhanced 3D FLAIR in orbital MRI.

Enhanced detection of optic neuritis with contrast-enhanced 3D FLAIR in orbital MRI.

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