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Cohort studyJournal of clinical medicine · 2026

MRI-Based Texture Analysis of the Extraocular Optic Nerve in Idiopathic Parkinson's Disease.

Seda Nida Karakucuk, Murat Baykara, Cemile Buket Tugan Yıldız

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OphthalmologyCohort study

Optic nerve sheath diameter is larger in Parkinson's disease patients than in healthy controls

MRI-Based Texture Analysis of the Extraocular Optic Nerve in Idiopathic Parkinson's Disease.

Seda Nida Karakucuk … Cemile Buket Tugan Yıldız

Journal of clinical medicine · 2026

Purpose

To evaluate microstructural and morphological alterations of the extraocular optic nerve in patients with idiopathic Parkinson's disease (IPD) using MRI-based texture analysis and to compare these findings with those of healthy controls.

Methods

This retrospective study included 74 participants (37 IPD patients and 37 age- and sex-matched controls).

n = 74 participants

Results

sheath around the optic nerve measured wider in Parkinson's than in healthy eyes

5.2mm

IPD

3.2mm

Controls

More results

No significant differences were observed between groups regarding age or sex ( p > 0.05).

Histogram analysis demonstrated significantly lower entropy values in patients with IPD ( p < 0.05).

More results

In GLRLM analysis, short-run emphasis and high gray-level run emphasis were significantly lower, whereas long-run emphasis and low gray-level run emphasis were significantly higher in the IPD group ( p < 0.05).

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Conclusion

MRI-based texture analysis reveals significant structural and microstructural alterations in the extraocular optic nerve in IPD, supporting its potential role as a non-invasive imaging biomarker for subclinical visual pathway involvement.

Post

MRI-Based Texture Analysis of the Extraocular Optic Nerve in Idiopathic Parkinson's Disease.

Optic nerve sheath diameter is larger in Parkinson's disease patients than in healthy controls

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