Multifractionation knowledge-based planning model for the stereotactic treatment of ocular tumors.

StudyMedical dosimetry : official journal of the American Association of Medical Dosimetrists· Jul 2026

Multifractionation knowledge-based planning model for the stereotactic treatment of ocular tumors.

Chase Cochran, Shane McCarthy, William St Clair, Damodar Pokhrel

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Ocular OncologyStudyClinical practiceQ2IF 1.8

Automated planning tool creates ocular tumor radiotherapy plans in about 14 minutes

Multifractionation knowledge-based planning model for the stereotactic treatment of ocular tumors.

Chase Cochran … Damodar Pokhrel

Medical dosimetry · Jul 2026

Background

Linear accelerator-based stereotactic radiosurgery and stereotactic radiotherapy (SRS/SRT) are commonly used in the treatment of ocular malignancies.

Methods

The knowledge-based planning (knowledge-based planning) model was trained on 86 synthetic HyperArc plans and retrospectively tested on 24 datasets.

n = 24 datasets

∼14 minutes

Results

∼14 minutes

planning took roughly this long - fast enough to try several treatment options per patient

n = 24 datasets

More results

A previously validated HyperArc-based RapidPlan model for single-fraction (25 Gy) ocular SRS was adapted and further trained to handle 3- and 5-fraction prescriptions (42 Gy/3 Fx and 50 Gy/5 Fx).

More results

Across 1-, 3-, and 5-fraction ocular SRS/SRT regimens, the knowledge-based planning model-based plans produced comparable target conformity, gradient, homogeneity, and coverage metrics, with no clinically meaningful differences between fractionation schemes.

Differences in mean target dose (∼1%) were negligible.

“

Conclusion

The rapid generation of these knowledge-based planning plans allows multiple fractionation schemes to be explored on a per-patient basis in a timely manner that would otherwise be clinically impractical with conventional manual planning.

Multifractionation knowledge-based planning model for the stereotactic treatment of ocular tumors.

Multifractionation knowledge-based planning model for the stereotactic treatment of ocular tumors.

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