Heerfordt Syndrome Complicated by Bilateral Simultaneous Facial Palsy, PTH-Independent Hypercalcemia, and…

Case reportReports (MDPI)· Jul 2026

Heerfordt Syndrome Complicated by Bilateral Simultaneous Facial Palsy, PTH-Independent Hypercalcemia, and Bilateral Obstructive Acute Kidney Injury in the Absence of Thoracic Disease: A Case Report and Narrative Review.

Khaled Abdulwahab Amer, Nawaf Ibrahim Al Shuqayfah, Mohammad Abdallah Alhakamy, Abdullah Jaber Alasiri

OphthalmologyCase reportDiagnosis

Sarcoidosis-related uveoparotid fever caused calcitriol-driven hypercalcemia without lung disease

Heerfordt Syndrome Complicated by Bilateral Simultaneous Facial Palsy, PTH-Independent Hypercalcemia, and Bilateral Obstructive Acute Kidney Injury in the Absence of Thoracic Disease: A Case Report and Narrative Review.

Khaled Abdulwahab Amer … Abdullah Jaber Alasiri

Reports (MDPI) · Jul 2026

Background

Heerfordt syndrome (uveoparotid fever) is an uncommon extrapulmonary expression of sarcoidosis defined by parotid enlargement, uveitis, low-grade fever, and facial nerve palsy.

13.1

Results

13.1

mg/dL

peak blood calcium was well above normal, confirming hypercalcemia

More results

It is identified in fewer than 1% of patients with biopsy-confirmed sarcoidosis, and the co-occurrence of bilateral seventh-nerve palsy with calcitriol-driven obstructive kidney injury has been reported only sporadically.

More results

Case Presentation : A 30-year-old man presented with four months of progressive bilateral parotid swelling, sicca symptoms, and intermittent blurred vision, preceded by a self-limited episode of bilateral simultaneous peripheral facial weakness; renal colic developed one month before admission.

Posterior uveitis was confirmed ophthalmologically.

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Conclusion · 1 of 2

This report characterizes a phenotype that combines bilateral simultaneous facial-nerve involvement, calcitriol-mediated hypercalcemia, and obstructive nephrolithiasis without coexistent pulmonary disease.

Conclusion · 2 of 2

It argues for early consideration of sarcoidosis whenever hypercalcemia, parotid enlargement, and cranial neuropathy occur together, and reinforces the reversibility of sarcoidosis-related renal injury when corticosteroids are introduced promptly.

Heerfordt Syndrome Complicated by Bilateral Simultaneous Facial Palsy, PTH-Independent Hypercalcemia, and Bilateral Obstructive Acute Kidney Injury in the Absence of Thoracic Disease: A Case Report and Narrative Review.

Heerfordt Syndrome Complicated by Bilateral Simultaneous Facial Palsy, PTH-Independent Hypercalcemia, and Bilateral Obstructive Acute Kidney Injury in the Absence of Thoracic Disease: A Case Report and Narrative Review.

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